Folate-Based Near-Infrared Fluorescent Theranostic Gemcitabine Delivery

Extra Form
author Jong Seung Kim
journal J. Am. Chem. Soc. 2013, 135, 11657-11662
Homepage http://orgchem.korea.ac.kr/index2.asp
?

단축키

Prev이전 문서

Next다음 문서

ESC닫기

+ - Up Down Comment Print
Abstract

A series of heptamethine cyanine (1−3) derivatives bearing a carbamate ethyl disulfide group and gemcitabine, an anticancer drug, have been newly synthesized. Their disulfide bonds are readily cleaved by various thiols including glutathione, to result in a subsequent decomposition of the carbamate into amine followed by release of the active gemcitabine, which can be monitored by the fluorescence changes. In the biological experiment, prodrug 1 is preferentially up-taken by folate-positive KB cells over folatenegative A549 cells via receptor-mediated endocytosis to release gemcitabine causing cell death and to emit fluorescence in endoplasmic reticulum. Moreover, it is selectively accumulated in the KB cells which were treated to mice by dorsal subcutaneous injection. This drug delivery system is a new theranostic agent, wherein both therapeutic effect and drug uptake can be easily monitored at the subcellular level, by in vivo and in vitro ufluorescence imaging.

research56_img.jpg


http://pubs.acs.org/doi/abs/10.1021/ja405372k


Articles

1 2 3 4 5 6

Designed by sketchbooks.co.kr / sketchbook5 board skin

나눔글꼴 설치 안내


이 PC에는 나눔글꼴이 설치되어 있지 않습니다.

이 사이트를 나눔글꼴로 보기 위해서는
나눔글꼴을 설치해야 합니다.

설치 취소

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5

Sketchbook5, 스케치북5