From p-Xylene to Ibuprofen in Flow: 3-Step Synthesis via Unified Sequence of Chemoselective C–H Metalations

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author Heejin Kim
journal Chem. Eur. J. 2019, 25, accepted article.
Homepage https://gowithflow.wixsite.com/hkim
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Heejin Kim (교신저자)


Ibuprofen was prepared from an inactive and inexpensive p-xylene by 3-step flow functionalizations through chemoselective metalations of benzyl positions in sequence using an in-situ generated LICKOR-type superbase. The flow approach in the microreactor facilitated to comprehensively explore over 100 conditions in the first-step reaction by varying concentrations, temperatures, solvents, and equivalents of reagents, enabling to find the optimal condition with 95% yield by significantly suppressing the formation of byproducts, followed by the second C–H metalation step in 95% yield. Moreover, gram-scale synthesis of ibuprofen in the final step was achieved by biphasic flow reaction of solution-phase intermediate with CO2, isolating 2.3 g for 10 min of operation time.


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https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201903267  



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