첨부 '3' |
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author | Jong Seung Kim |
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journal | Journal of the American Chemical Society |
Homepage | http://orgchem.korea.ac.kr/ |
김지현(제1저자, 석박사통합과정 8학기)
Breast cancer consists of heterogenic subpopulations, which determine the prognosis and response to chemotherapy. Among these subpopulations, a very limited number of cancer cells are particularly problematic. These cells, known as breast cancer stem cells (BCSCs), are thought responsible for metastasis and recurrence. They are thus major contributor to the unfavorable outcomes seen for many breast cancer patients. BCSCs are more prevalent in the hypoxic niche. This is an oxygen-deprived environment that is considered crucial to their proliferation, stemness, and self-renewal but also one that makes BCSCs highly refractory to traditional chemotherapeutic regimens. Here we report a small molecule construct, AzCDF, that allows the therapeutic targeting of BCSCs and which is effective in normally refractory hypoxic tumor environments. A related system, AzNap, has been developed that permits CSC imaging. Several design elements are incorporated into AzCDF, including the CAIX inhibitor acetazolamide (Az) to promote localization in MDA-MB-231 CSCs, a dimethylnitrothiophene subunit as a hypoxia trigger, and a 3,4-difluorobenzylidene curcumin (CDF) as a readily released therapeutic payload. This allows AzCDF to serve as a hypoxia-liable molecular platform that targets BCSCs selectively which decreases CSC migration, retards tumor growth, and lowers tumorigenesis rates as evidenced by a combination of in vitro and in vivo studies. To the best of our knowledge, this is the first time a CSC-targeting small molecule has been shown to prevent tumorigenesis in an animal model.
https://pubs.acs.org/doi/10.1021/jacs.1c03875
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Direct C–H metallation of tetrahydrofuran and application in flow
The direct C–H metallation of tetrahydrofuran (THF) to generate α-anionic THF is one of the most straightforward methods for the the generation and utilization of α-anionic THF. Here we develop a reaction for the direct me... -
Functionalization of Diamine-Appended MOF-Based Adsorbents by Ring Opening of Epoxide: Long-Term Stability and CO2 Recyclability under Humid Conditions
Although diamine-appended metal-organic framework (MOF) adsorbents exhibit excellent CO2 adsorption performance, a continuous decrease in long-term capacity during repeated wet cycles remains a formidable challenge for practical application... -
High Gravimetric and Volumetric Ammonia Capacities in Robust Metal–Organic Frameworks Prepared via Double Postsynthetic Modification
Ammonia is a promising energy vector that can store the high energy density of hydrogen. For this reason, numerous adsorbents have been investigated as ammonia storage materials, but ammonia adsorbents with a high gravimetric/volumetric amm... -
Li-ion Intercalation, Rectification, and Solid Electrolyte Interphase in Molecular Tunnel Junctions
This paper describes Li-ion intercalation into pyrenyl terminated self-assembled monolayer (SAM) on gold, inspired from graphite anode in Li-ion battery, and its effect on tunneling performance in molecular junction incorporating the SAM. A... -
Thermopower of Molecular Junction in Harsh Thermal Environments
Molecular junctions can be miniaturized devices for heat-to-electricity conversion application, yet these operate only in mild thermal environments (less than 323 K) because thiol, the most widely used anchor moiety for chemisorption of act... -
Microfluidics-Assisted Synthesis of Hierarchical Cu2O Nanocrystal as C2-Selective CO2 Reduction Electrocatalyst
Copper-based catalysts have attracted enormous attention due to their high selectivity for C2+ products during the electrochemical reduction of CO2 (CO2RR). In particular, grain boundaries on the catalysts contribute to the generation of va... -
Chemical Fields: Directing Atom Migration in the Multiphasic Nanocrystal
Atoms in a bulk solid phase are usually trapped to fixed positions and can change their position only under certain conditions (e.g., at a melting point) due to the high energy barrier of migration between positions within the crystal latti... -
Electronic Mechanism of In Situ Inversion of Rectification Polarity in Supramolecular Engineered Monolayer
This paper describes polarity inversion in molecular rectification and the related mechanism. Using supramolecular engineered, ultrastable binary mixed self-assembled monolayer (SAM) composed of organic molecular diode (SC11BIPY) and inert ... -
Direct observation of protein structural transitions through entire amyloid aggregation processes in water using 2D-IR spectroscopy
Amyloid proteins that undergo self-assembly to form insoluble fibrillar aggregates have attracted much attention due to their role in biological and pathological significance in amyloidosis. This study aims to understand the amyloid aggrega... -
Harnessing GLUT1-Targeted Pro-oxidant Ascorbate for Synergistic Phototherapeutics
Despite extensive efforts to realize effective photodynamic therapy (PDT), there is still a lack of therapeutic approaches concisely structured to mitigate the major obstacles of PDT in clinical applications. Herein, we report a molecular s... -
DNA-Damage-Response-Targeting Mitochondria-Activated Multifunctional Prodrug Strategy for Self-Defensive Tumor Therapy
We report a novel multifunctional construct, M1, designed explicitly to target the DNA damage response in cancer cells. M1 contains both a floxuridine (FUDR) and protein phosphatase 2A (PP2A) inhibitor combined with a GSH-sensitive linker. ... -
Midwavelength Infrared Colloidal Nanowire Laser
Realizing bright colloidal infrared emitters in the midwavelength infrared (or mid-IR), which can be used for low-power IR light-emitting diodes (LEDs), sensors, and deep-tissue imaging, has been a challenge for the last few decades. Here, ... -
Kinetic Modulation of Amyloid-β (1–42) Aggregation and Toxicity by Structure-Based Rational Design
임동준 (제1저자, 통합과정생) Several point mutations can modulate protein structure and dynamics, leading to different natures. Especially in the case of amyloidogenic proteins closely related to neurodegenerative diseases, structural chang... -
Safeguarding the RuO2 phase against lattice oxygen oxidation during acidic water electrooxidation
Defective RuO2 possesses excellent initial activity toward the oxygen evolution reaction in acidic water electrooxidation due to the involvement of lattice oxygens, which, however, is the very reason for the accelerated dissolution of Ru sp... -
Mn-dopant differentiating the Ru and Ir oxidation states in catalytic oxides toward durable oxygen evolution reaction in acidic electrolyte
Designing an efficient and durable electrocatalyst for the sluggish oxygen evolution reaction (OER) at the anode remains the foremost challenge in developing proton exchange membrane (PEM) electrolyzers. Here we report a highly active and d... -
Dynamic Water Promotes Lithium-Ion Transport in Superconcentrated and Eutectic Aqueous Electrolytes
김준규(제1저자, 통합과정) Superconcentrated aqueous electrolytes have shown promise as safe and high-voltage lithium-ion battery (LIB) electrolytes. However, the interplay of lithium-ion solvation structure and dynamics with fast Li-ion tra... -
Isomeric sp2-C conjugated Porous Organic Polymer-mediated Photo- and Sono-catalytic Detoxification of Sulfur Mustard Simulant under Ambient Conditions
The development of efficient strategies for the sustainable detoxification of mustard gas simulants has longstanding demand for human safety. Here, we present for the first time a photo- and sono-catalyzed selective detoxification of mustar... -
Vertical-crystalline Fe-doped β-Ni oxyhydroxides for highly active and stable oxygen evolution reaction
김병윤 (제1저자, 기초과학연구원) The layered transition metal oxyhydroxides have received increasing interest owing to the efficient energy conversion performance and material stability during the oxygen evolution reaction (OER). In particu... -
Extended Short-Wavelength Infrared Photoluminescence and Photocurrent of Nonstoichiometric Silver Telluride Colloidal Nanocrystals
김가현(제1저자, 석박통합과정) Demands on nontoxic nanomaterials in the short-wavelength infrared (SWIR) have rapidly grown over the past decade. Here, we present the nonstoichiometric silver chalcogenide nanocrystals of AgxTe (x > 2) and Ag... -
Enhanced Thermopower of Saturated Molecules by Noncovalent Anchor-Induced Electron Doping of Single-Layer Graphene Electrode
Enhancing thermopower is a key goal in organic and molecular thermoelectrics. Herein, it is shown that introducing noncovalent contact with a single-layer graphene (SLG) electrode improves the thermopower of saturated molecules as compared ...