Research Highlight

  1. Folate-Based Near-Infrared Fluorescent Theranostic Gemcitabine Delivery

    Jong Seung Kim
    J. Am. Chem. Soc. 2013, 135, 11657-11662
    Abstract A series of heptamethine cyanine (1−3) derivatives bearing a carbamate ethyl disulfide group and gemcitabine, an anticancer drug, have been newly synthesized. Their disulfide bonds are readily cleaved by various thiols including glu...
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  2. An Activatable Theranostic for Targeted Cancer Therapy and Imaging

    Jong Seung Kim
    Journal : Angew. Chem. Int. Ed. 2014, 53, 4469 – 4474
    Abstract A new theranostic strategy is described. It is based on the use of an “all in one” prodrug, namely the biotinylated piperazine-rhodol conjugate 4 a. This conjugate, which incorporates the anticancer drug SN-38, undergoes se...
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  3. Toward a Chemical Marker for Inflammatory Disease: A Fluorescent Probe for Membrane-Localized

    Jong Seung Kim
    J. Am. Chem. Soc. 2014, 136, 8430 – 8437
    Abstract Thioredoxin (Trx) is a redox-active protein that plays a key role in mitigating the effects of oxidative stress. The secretion of Trx on the plasma membrane has been suggested as a distinctive feature of inflammation. Howev...
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