세미나 Seminars

Extra Form
초청강사 기정민 교수
소속 UNIST 화학과
일시 2015년 9월 17일(목) 오후5시
장소 아산이학관 331호
Chasing Phosphohistidine, “Dark Matter” in the Phosphoproteome


Abstract: 
My research program focuses on the synergistic combination of synthetic organic chemistry and protein 
chemistry for innovative applications in biology and medicine. I will discuss our recent work on 
phosphohistidine (pHis), a labile protein post-translational modification(PTM). Despite the long-recognized 
importance of pHis in cell signaling and metabolism,the full scope and exact function of protein histidine 
phosphorylation is not clearly understood. It is mainly due to the chronic lack of adequate research tools to 
investigate the unstable PTM. We provided first glimpse at this “dark matter” in the phosphoproteome through 
the development of novel chemical tools for studying histidine phosphorylation, including stable pHis analogs, 
pHis-specific antibodies, and bisubstrate analogs for histidine kinases.


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