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초청강사 이 선 우 교수
소속 전남대학교 화학과
일시 2021년 4월 1일(목) 오후 5:00
장소 ZOOM

 

Development of Synthetic Methods using

C-N Bond Activation

 

The amide functionality is one of the key structural motifs found in biological compounds such as peptides, proteins, and alkaloids. It is also widely used to prepare agrochemicals, pharmaceuticals, polymers, and materials. Therefore, a number of synthetic routes to amides have been reported. We developed the nickel-catalyzed transamidation of unactivated secondary amides and the Claisen condensation reaction between two different amides. It was found that nickel activated C-N bond of amides. In addition, the transamidation of primary amides at room temperature was developed by our group.1

We also reported the amide coupling reaction with carbon nucleophiles such as carbonyl compounds and aryl siloxanes to give the corresponding acylated products.2

  In this seminar, the details about our recent findings of the C-N bond activations for the synthesis of different type of amides and ketones will be presented.

 

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References

1. (a) S. Yu, T. Shin, M. Zhang, Y. Xia, H. Kim, S. Lee, Org. Lett. 2018, 20, 7563. (b) J. Chen, Y. Xia, S. Lee, Org. Lett. 2020, 22, 3504. (c) D. Yang, T. Shin, H. Kim, S. Lee. Org. Biomol. Chem. 2020, 18, 6053. (d) M. A. Idris, S. Lee, Org. Chem. Front. 2020, 7, 2737.

 

 

(a) J. Chen, M. Xu, S. Yu, Y. Xia, S. Lee, Org. Lett. 2020, 22, 2287. (b) J. Chen, Y. Xia, S. Lee, Org. Chem. Front. 2020, 7, 2931. (c) M. 2. A. Idris, S. Lee, Org. Lett. 2020. 22, 9190.

 

 

20210401_대학원세미나_이선우 교수.pdf