Research Highlight


김상인(제1저자, 통합과정생)

A novel strategy for designing highly efficient and activatable photosensitizers that can effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is proposed. Replacing both oxygen atoms in conventional naphthalimides (RNI-O) with sulfur atoms led to dramatic changes in the photophysical properties. The remarkable fluorescence quenching (ΦPL ≈ 0) of the resulting thionaphthalimides (RNI-S) suggested that the intersystem crossing from the singlet excited state to the reactive triplet state was enhanced by the sulfur substitution. Surprisingly, the singlet oxygen quantum yield of RNI-S gradually increased with increasing electron-donating ability of the 4-R substituents (MANI-S, ΦΔ ≈ 1.00, in air-saturated acetonitrile). Theoretical studies revealed that small singlet–triplet energy gaps and large spin–orbit coupling could be responsible for the efficient population of the triplet state of RNI-S. In particular, the ROS generation ability of MANI-S was suppressed under physiological conditions due to their self-assembly and was significantly recovered in cancer cells. More importantly, cellular experiments showed that MANI-S still produced a considerable amount of ROS even under severely hypoxic conditions (1% O2) through a type-I mechanism.


  1. Molecular Design of Highly Efficient Heavy-Atom-Free Triplet BODIPY Derivatives for Photodynamic Therapy and Bioimaging

    김상인 (제1저자, 석사과정) Novel BODIPY photosensitizers were developed for imaging‐guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement be...
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  2. Transformation of Colloidal Quantum Dot: From Intraband Transition to Localized Surface Plasmon Resonance

    최동선(공동1저자, 석박통합과정) 손주희(공동1저자, 석사과정) An increase in the carrier density of semiconductor nanocrystals can gradually change the origin of the optical property from the excitonic transition to the localized surface plas...
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  3. Mitochondrial Relocation of a Common Synthetic Antibiotic: A Non-genotoxic Approach to Cancer Therapy

    Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, o...
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  4. Significantly Improved Morphology and Efficiency of Nonhalogenated Solvent‐Processed Solar Cells Derived from a Conjugated Donor–Acceptor Block Copolymer

    박수홍 (제 1저자, 박사과정) A highly crystalline conjugated donor (D)–acceptor (A) block copolymer (PBDT2T‐b ‐N2200) that has good solubility in nonhalogenated solvents is successfully synthesized. PBDT2T‐b ‐N2200 shows a broad complementar...
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  5. Mechanical Force Induces Ylide-Free Cycloaddition of Nonscissible Aziridines

    정상민 (제1저자, 석박통합과정) Reported herein is that aziridines can be a nonvulnerable mechanophore. Upon exposure to a mechanical force, stereochemically pure nonactivated aziridines incorporated into the backbone of macromolecule do not...
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  6. Bright ligand-activatable fluorescent protein for high-quality multicolor live-cell super-resolution microscopy

    We introduce UnaG as a green-to-dark photoswitching fluorescent protein capable of high-quality super-resolution imaging with photon numbers equivalent to the brightest photoswitchable red protein. UnaG only fluoresces upon binding of a fluo...
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  7. Power Factor of One Molecule Thick Films and Length Dependence

    박소현 (제1저자, 통합과정) 강서현(공동 제1저자, 통합과정) There is a rapidly increasing interest in organic thin film thermoelectrics. However, the power factor of one molecule thick organic film, the self-assembled monolayer (SAM), has not...
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  8. An Emerging Molecular Design Approach to Heavy-Atom-Free Photosensitizers for Enhanced Photodynamic Therapy under Hypoxia

    김상인(제1저자, 통합과정생) A novel strategy for designing highly efficient and activatable photosensitizers that can effectively generate reactive oxygen species (ROS) under both normoxia and hypoxia is proposed. Replacing both oxygen atom...
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  9. Ga‐Based Liquid Metal Micro/Nanoparticles: Recent Advances and Applications

    송현선(지도교수: 윤효재), 김태경(지도교수: 이광렬), 강서현(지도교수: 윤효재), 진하늘(지도교수: 이광렬) /공동 제 1저자 Liquid metals are emerging as fluidic inorganic materials in various research fields. Micro‐ and nanoparticles of Ga and i...
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  10. A Hydrogen-Bonded Organic Framework with Type IV NH3 Adsorption Behavior

    Dong Won Kang(강동원, 통합과정, 제1저자) / Minjung Kang(강민정, 통합과정, 제2저자) An S‐shaped gas isotherm pattern displays high working capacity in pressure‐swing adsorption cycle, as established for CO2, CH4, acetylene, and CO. However, ...
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  11. Janus to Core-Shell to Janus: Facile Cation Movement in Cu2-xS/Ag2S Hexagonal Nanoplates Induced by Surface Strain Control

    김태경, 박종식, 홍용주 / 공동 제 1저자 Nanocrystals with multiple compositions and hetero-interfaces have received a great attention due to promising multifunctional and synergistic physicochemical properties. In particular, hetero-interfac...
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  12. Two Different Length-Dependent Regimes in Thermoelectric Large-Area Junctions of n-Alkanethiolates

    박소현(제1저자,통합과정생) Molecular thermoelectrics is relatively unexplored compared with its analogous research field, molecular electronics. This is surprising considering that the two research fields share an identical energy landscape...
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  13. From p-Xylene to Ibuprofen in Flow: 3-Step Synthesis via Unified Sequence of Chemoselective C–H Metalations

    Heejin Kim (교신저자) Ibuprofen was prepared from an inactive and inexpensive p-xylene by 3-step flow functionalizations through chemoselective metalations of benzyl positions in sequence using an in-situ generated LICKOR-type superbase. Th...
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  14. Mid-wavelength Infrared Photoluminescence and Lasing of Tellurium Element Solid and Microcrystals

    Dongsun Choi(제1저자, 통합과정) Tellurium has been of great interest in physics, chemistry, material science, and more recently in nanoscience. However, information on the photoluminescence of Te crystals, crucial in understanding the mater...
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  15. Structure–thermopower relationships in molecular thermoelectrics

    Sohyun Park (통합과정, 제1저자) Hungu Kang(Post-Doc. 제1저자) Studies of molecular thermoelectrics help to reveal how atomic-detailed structural modification in molecules can affect the thermopower of molecular-scale devices. This review co...
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  16. Cytoplasmic Protein Imaging with Mid-Infrared Photothermal Microscopy: Cellular Dynamics of Live Neurons and Oligodendrocytes

    Chanjong Park(통합과정, 제1저자) Mid-infrared photothermal microscopy has been suggested as an alternative to conventional infrared microscopy because in addition to the inherent chemical contrast available upon vibrational excitation, it c...
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  17. Conjugated Polyelectrolytes as Multifunctional Passivating and Hole‐Transporting Layers for Efficient Perovskite Light‐Emitting Diodes

    Thanh Luan Nguyen(Post-Doc. 제1저자) Metal halide perovskites (MHPs) have attracted significant attention as light‐emitting materials owing to their high color purities and tunabilities. A key issue in perovskite light‐emitting diodes (PeLE...
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  18. Covalently Linked Perylene Diimide–Polydiacetylene Nanofibers Display Enhanced Stability and Photocurrent with Reversible FRET Phenomenon

    Because of their unique structural and optical properties, 1D perylene diimide (PDI) derivatives have gained attention for use in optoelectronic devices. However, PDI‐containing self‐assembled supramolecular systems often are of limited use ...
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  19. Blue Emission of α-GaN Colloidal Quantum Dots via Zn Doping

    Yun Chang Choi(최윤창, 제1저자) Gallium nitride (GaN) has been of interest due to its enormous potentials for optoelectronic devices. However, it is very interesting that no proper bottom-up chemical synthesis method for GaN quantum dot has...
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  20. Gas phase conformations of intrinsically disordered proteins and their complexes with ligands: Kinetically trapped states during transfer from solution to the gas phase

    Jong Yoon Han(한종윤, 제1저자, 박사과정) Flexible structures of intrinsically disordered proteins (IDPs) are crucial for versatile functions in living organisms, which involve interaction with diverse partners. Electrospray ionization ion m...
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