|author||Hugh I. Kim|
|journal||Angew. Chem. Int. Ed. 2018 (DOI: 10.1002/anie.201712286)|
Tae Su Choi(Post doc.) / Jong Yoon Han(박사과정)
Structural variation of α-synuclein (αSyn) fibrils has been linked to the diverse etiologies of synucleinopathies. However, little is known about what specific mechanism provides αSyn fibrils with pathologic features. Herein, we demonstrate Cu(II)-based supra-molecular approach for unraveling the formation process of pathogenic αSyn fibrils and its application in a neurotoxic mechanism study. The conformation of αSyn monomer was strained by macrochelation with Cu(II), thereby disrupting the fibril elongation while promoting its nucleation. This non-canonical process formed shortened, β-sheet enriched αSyn fibrils (< 0.2 µm) that were rapidly transmitted and accumulated to neuronal cells, causing neuronal cell death, in sharp contrast to typical αSyn fibrils (~1 µm). Our approach provided the supramolecular basis for the formation of pathogenic fibrils through physiological factors such as brain Cu(II).
« Prev Molecular Role of Ca2+ and Hard Divalent Metal Cations on Acc...Molecular Role of Ca2+ and Hard Divalent Metal Cations on Acc... 2018.01.31by 〈
Recent Progress in the Chemistry of Pyridazinones for Functio... Next »Recent Progress in the Chemistry of Pyridazinones for Functio... 2017.12.06by 〉
Designed by sketchbooks.co.kr / sketchbook5 board skin