첨부 '1' |
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author | Jong Seung Kim |
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journal | J. Am. Chem. Soc. 2013, 135, 9181−9185 |
Homepage | http://orgchem.korea.ac.kr/index2.asp |
Abstract
High-tech pH paper : A self-calibrating bipartite viscosity sensor 1 for cellular mitochondria, composed of coumarin and boron-dipyrromethene (BODIPY) with a rigid phenyl spacer and a mitochondria-targeting unit, was synthesized. The sensor showed a direct linear relationship between the fluorescence intensity ratio of BODIPY to coumarin or the fluorescence lifetime ratio and the media viscosity, which allowed us to determine the average mitochondrial viscosity in living HeLa cells as ca. 62 cP (cp). Upon treatment with an ionophore, monensin, or nystatin, the mitochondrial viscosity was observed to increase to ca. 110cP.
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http://pubs.acs.org/doi/abs/10.1021/ja403851p
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A High Efficiency Nonfullerene Organic Solar Cell with Optimized Crystalline Organizations
A well-organized donor–acceptor crystalline structure is examined for high performance nonfullerene solar cells. By thermal annealing, nanoscale structures of both donor and acceptor domains are successfully modulated, followed by signific... -
Diastereomeric Resolution of a Racemic Biaryl Boronic Acid and Its Application to Divergent Asymmetric Total Syntheses of Some Axially Chiral Natural Products
The asymmetric total syntheses of deshydroxy-tetramethylcupressuflavone and desmethylkotanin and the synthesis of a key intermediate in the previous synthesis of hibarimicinone were described using an axially chiral biaryl boronic acid, prep... -
Origin of the Reversible Thermochromic Properties of Polydiacetylenes Revealed by Ultrafast Spectroscopy
Polydiacetylenes (PDAs) with thermochromic properties undergo colorimetric transitions when the external temperature is varied. This capability has the potential to enable these materials to be used as temperature sensors. These thermochromi... -
Facet-controlled hollow Rh2S3 hexagonal nanoprisms as highly active and structurally robust catalysts toward hydrogen evolution reaction
Hollow Rh2S3 hexagonal nanoprisms, prepared by one-step formation of Cu1.94S@Rh2S3core-shell nanoprisms followed by the etching of core, exhibit very high catalytic activity and excellent stability toward hydrogen evolution reaction under ha... -
High Aspect Ratio Conjugated Polymer Nanowires for High Performance Field-Effect Transistors and Phototransistors
We synthesized a highly crystalline DPP-based polymer, DPPBTSPE, which contained 1,2-bis(5-(thiophen-2-yl)selenophen-2-yl)ethene as a planar and rigid electron donating group. High- and low-molecular weight (MW) DPPBTSPE fractions were colle... -
Supramolecular Enhancement of Protein Analysis via the Recognition of Phenylalanine with Cucurbit[7]uril
Mass spectrometry (MS)-based analysis using enzymatic digestion is widely used for protein sequencing and characterization. The large number of peptides generated from proteolysis, however, suppresses the signal of peptides with low ionizati... -
Disulfide-Based Multifunctional Conjugates for Targeted Theranostic Drug Delivery
Theranostics, chemical entities designed to combine therapeutic effects and imaging capability within one molecular system, have received considerable attention in recent years. Much of this interest reflects the promise inherent in personal... -
Spectroscopically tracking charge separation in polymer : fullerene blends with a three-phase morphology
The coexistence of intermixed amorphous polymer : fullerene phases alongside pure semicrystalline polymer and fullerene phases provides a plausible explanation for effective charge separation in organic photovoltaic blends by providing a cas... -
Chromogenic/Fluorogenic Ensemble Chemosensing Systems
Nature has endowed human beings with many useful functions, by virtue of supramolecular chemistry. As is well-known, nature can self-assemble relatively small molecular precursors into very complicated biomolecules. These supramolecular ense... -
Skeletal Octahedral Nanoframe with Cartesian Coordinates via Geometrically Precise Nanoscale Phase Segregation in a Pt@ Ni Core-Shell Nanocrystal
Catalytic properties of nanoparticles can be significantly enhanced by controlling nanoscale alloying and its structure. In this work, by using a facet-controlled Pt@Ni coreshell octahedron nanoparticle, we show that the nanoscale phase segr... -
Diketopyrrolopyrrole: brilliant red pigment dye-based fluorescent probes and their applications
The development of fluorescent probes for the detection of biologically relevant species is a burgeoning topic in the field of supramolecular chemistry. A number of available dyes such as rhodamine, coumarin, fluorescein, and cyanine have be... -
Enhanced NIR Radiation-Triggered Hyperthermia by Mitochondrial Targeting
Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular... -
Temperature-dependent dynamics of water in aqueous NaPF6 solution
Dynamics of water in bulk and ionic hydration shells in aqueous ionic solutions are different because of the local environments. However, direct measurements of the dynamics of water in ionic hydration shells apart from those of bulk water a... -
Diamine-functionalized metal–organic framework: exceptionally high CO2 capacities from ambient air and flue gas, ultrafast CO2 uptake rate, and adsorption mechanism
A framework en-Mg2(dobpdc) (1-en; en = ethylenediamine) functionalized with the primary amine en was prepared via postmodification. From synchrotron PXRD data, it is revealed that the cell parameters change upon grafting of en and CO2 uptake... -
pH-Dependent Proton Conducting Behavior in a Metal–Organic Framework Material
A porous metal–organic framework (MOF), [Ni2(dobdc)(H2O)2]⋅6 H2O (Ni2(dobdc) or Ni-MOF-74; dobdc4−=2,5-dioxido-1,4-benzenedicarboxylate) with hexagonal channels was synthesized using a microwave-assisted solvothermal reaction. Soaking Ni2(do... -
Template-Guided Solution-Shearing Method for Enhanced Charge Carrier Mobility in Diketopyrrolopyrrole-Based Polymer Field-Effect Transistors
Template-guided solution-shearing (TGSS) is used to fabricate field-effect transistors (FETs) composed of micropatterned prisms as active channels. The prisms comprise highly crystalline PTDPP-DTTE, in which diketopyrrolopyrrole (DPP) is fla... -
Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment
Activation of apoptosis, the cell death machinery, in tumor cells by organelle-specific delivery of antitumor theranostic agent is the utmost challenge in cancer therapy. Herein, we developed a highly efficient mitochondria-targeting antitum... -
Two-Color Probe to Monitor a Wide Range of pH Values in Cells
Abstract High-tech pH paper : A “chameleon” pH probe composed of rhodamine (red, see scheme) and fluorescein (green) units emits at wavelengths of 580 nm and 512 nm, where the intensities show a contrary response to pH changes. Confocal micr... -
A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria
Abstract High-tech pH paper : A self-calibrating bipartite viscosity sensor 1 for cellular mitochondria, composed of coumarin and boron-dipyrromethene (BODIPY) with a rigid phenyl spacer and a mitochondria-targeting unit, was synthesized. Th... -
Folate-Based Near-Infrared Fluorescent Theranostic Gemcitabine Delivery
Abstract A series of heptamethine cyanine (1−3) derivatives bearing a carbamate ethyl disulfide group and gemcitabine, an anticancer drug, have been newly synthesized. Their disulfide bonds are readily cleaved by various thiols including glu...