To see the unseen: digital holography for biomedicine & nanotechnology

Abstract: 

Digital holographic techniques, especially holographic imaging and shaping of light wavefront, allow the full access to light information and light-matter interaction. By digitally recording the wavefront of the laser beam interacting biological samples, biophysical information about live biological cells can be quantitatively retrieved, from which pathophysiological conditions of the cell can be studies: pathophysiology of red blood cell1; optical detection of bacterial species, in-vivo imaging of blood circulations.

By adaptively shaping the wavefront of a laser beam, multiple light scattering can be systematically controlled. Scattered light allows us to access large degree of freedom of light propagation; even spectral and polarization dependency of the light can be simply controlled. Recently, we demonstrate the concept of a scattering super-lens and the delivery of optical information through light scattering medium. 

1. Y Kim et al., Profiling individual human red blood cells using common-path diffraction optical tomography, Scientific Reports, 4, 6659, (2014)

2. C Park et al., Full-Field Subwavelength Imaging Using a Scattering Superlens, Phys. Rev. Lett. 113, 113901, (2014)

3. Y Jo et al., Angle-resolved light scattering of individual rod-shaped bacteria based on Fourier transform light scattering, Scientific Reports, 4, 5090, (2014)

4. J-H Park et al., Subwavelength light focusing using random nanoparticles, Nature Photonics, 7, 454, (2013)