Total Syntheses of Arcyriaflavin A and Calothrixin B Using 2,2′-Bisindole-3-acetic Acid Derivative as a Common Intermediate
| author | Cheol-Hong Cheon |
|---|---|
| journal | Org. Lett., 2017, 19 (11), pp 2785–2788 |
| Homepage | https://sites.google.com/site/cheonresearchlab/ |
| 첨부파일 '3' |
|---|
Sungjong Lee(석사과정) / Kyung-Hee Kim(박사과정)
A new protocol for the synthesis of 2,2′-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyanide-catalyzed imino-Stetter reaction. With this protocol, the divergent total syntheses of arcyriaflavin A, a representative indolocarbazole natural product, and calothrixin B, a representative indolo[3,2-j]phenanthridine natural product, were completed using a 2,2′-bisindole-3-acetic acid derivative as the common intermediate.
http://pubs.acs.org/doi/full/10.1021/acs.orglett.7b00687
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