첨부 '2' |
---|
author | Hugh I. Kim |
---|---|
journal | Angew. Chem. Int. Ed. 2018 (DOI: 10.1002/anie.201712286) |
Homepage | https://sites.google.com/site/hughkimgroup/ |
Tae Su Choi(Post doc.) / Jong Yoon Han(박사과정)
Structural variation of α-synuclein (αSyn) fibrils has been linked to the diverse etiologies of synucleinopathies. However, little is known about what specific mechanism provides αSyn fibrils with pathologic features. Herein, we demonstrate Cu(II)-based supra-molecular approach for unraveling the formation process of pathogenic αSyn fibrils and its application in a neurotoxic mechanism study. The conformation of αSyn monomer was strained by macrochelation with Cu(II), thereby disrupting the fibril elongation while promoting its nucleation. This non-canonical process formed shortened, β-sheet enriched αSyn fibrils (< 0.2 µm) that were rapidly transmitted and accumulated to neuronal cells, causing neuronal cell death, in sharp contrast to typical αSyn fibrils (~1 µm). Our approach provided the supramolecular basis for the formation of pathogenic fibrils through physiological factors such as brain Cu(II).
http://onlinelibrary.
-
Accurate Quantification of N-glycolylneuraminic Acid in Therapeutic Proteins Using Supramolecular Mass Spectrometry
Hyun Hee L. Lee (이현희, 박사과정, 제1저자) / Chae Eun Heo (허채은, 박사과정, 제 2저자) Practical applications of innovative host-guest systems are challenging because of unexpected guest competitors and/or subtle environmental differences.... -
Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug
Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here we report a new approach to overcoming resistance that involves rep... -
Janus Nanoparticle Structural Motif Control via Asymmetric Cation Exchange in Edge-Protected Cu1.81S@IrxSy Hexagonal Nanoplates
Post-synthetic transformation of nanoparticles has received great attention, because this approach can provide an unusual route to elaborately composition-controlled nanostructures while maintaining the overall structure of the template. In... -
Deconvolution of Tunneling Current in Large-area Junctions Formed with Mixed Self-Assembled Monolayers
Junji Jin(석사과정) Gyu Don Kong(박사과정) Whereas single-component self-assembled monolayers (SAMs) have served widely as organic components in molecular and organic electronics, how the performance of the device is influenced by the hetero... -
Electron heating and thermal relaxation of gold nanorods revealed by two-dimensional electronic spectroscopy
To elucidate the complex interplay between the size and shape of gold nanorods and their electronic, photothermal, and optical properties for molecular imaging, photothermal therapy, and optoelectronic devices, it is a prerequisite to charac... -
(Semi)ladder-Type Bithiophene Imide-Based All-Acceptor Semiconductors: Synthesis, Structure–Property Correlations, and Unipolar n-Type Transistor Performance
Development of high-performance unipolar n-type organic semiconductors still remains as a great challenge. In this work, all-acceptor bithiophene imide-based ladder-type small molecules BTIn and semiladder-type homopolymers PBTIn (n = 1–5) w... -
Dendrite-Embedded Platinum–Nickel Multiframes as Highly Active and Durable Electrocatalyst toward the Oxygen Reduction Reaction
Hyukbu Kwon(석사과정) Jongsik Park(박사과정) Pt-based nanoframe catalysts have been explored extensively due to their superior activity toward the oxygen reduction reaction (ORR). Herein, we report the synthesis of Pt–Ni multiframes, which ... -
Mid-Infrared Intraband Transition of Metal Excess Colloidal Ag2Se Nanocrystals
Mihyeon Park(석사과정) Dongsun Choi(박사과정) Steady-state intraband transition, which is a promising electronic transition of a colloidal quantum dot along with the band-gap transition, had been a long-standing challenge. The steady-state ... -
Enhanced Electron Transfer Mediated by Conjugated Polyelectrolyte and Its Application to Washing-Free DNA Detection
Ji-Eun Jeong (박사과정) Direct electron transfer between a redox label and an electrode requires a very short working distance (<1-2 nm), and in general an affinity biosensor based on the direct electron transfer requires a finely smoothed ... -
Vertex-reinforced PtCuCo ternary nanoframes as efficient and stable electrocatalysts for the oxygen reduction reaction and the methanol oxidation reaction
Taehyun Kwon(박사과정) / Minki Jun (박사과정) Noble metal binary alloy nanoframes have emerged as a new class of fuel cell electrocatalysts because of their intrinsic high catalytic surface area and accompanied high catalytic activity. Howe... -
Molecular Role of Ca2+ and Hard Divalent Metal Cations on Accelerated Fibrillation and Interfibrillar Aggregation of α-Synuclein
Jong Yoon Han(박사과정) / Tae Su Choi(Post doc.) α-Synuclein (αSyn) is an intrinsically disordered protein, the aggregation of which is highly related to the pathology of diverse α-synucleinopathies. Various hard divalent metal cations have... -
Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Cu(II) Coordination
Tae Su Choi(Post doc.) / Jong Yoon Han(박사과정) Structural variation of α-synuclein (αSyn) fibrils has been linked to the diverse etiologies of synucleinopathies. However, little is known about what specific mechanism provides αSyn fibrils... -
Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations
Seohyun Kang(석사과정) While N-hetereocycles have received significant attention in organic synthesis and other research fields, the chemistry of pyridazine, six-membered aromatic ring with adjacent two nitrogen atoms, and its derivatives ... -
Maskless Arbitrary Writing of Molecular Tunnel Junctions
Seo Eun Byeon(석사과정) / Miso Kim(석사과정) Since fabricating geometrically well-defined, noninvasive, and compliant electrical contacts over molecular monolayers is difficult, creating molecular-scale electronic devices that function in h... -
Single Component Organic Solar Cells Based on Oligothiophene-Fullerene Conjugate
Thanh Luan Nguyen(Post doc.) A new donor (D)–acceptor (A) conjugate, benzodithiophene-rhodanine–[6,6]-phenyl-C61 butyric acid methyl ester (BDTRh–PCBM) comprising three covalently linked blocks, one of p-type oligothiophene containing BDTRh... -
Lanthanide metal-assisted synthesis of rhombic dodecahedral MNi (M=Ir and Pt) nanoframes toward efficient oxygen evolution catalysis
Haneul Jin(박사과정) / Yongju Hong(박사과정) Mixed metal alloy nanoframeworks have shown a great promise as electrocatalysts in water electrolyzers and fuel cells. Although a limited number of mixed metal alloy nanoframeworks have been synt... -
Radially Phase Segregated PtCu@PtCuNi Dendrite@Frame Nanocatalyst for the Oxygen Reduction Reaction
Hyukbu Kwon(석사과정) / Jongsik Park(박사과정) Pt-based alloy nanoframes have shown a great potential as electrocatalysts toward oxygen reduction reaction (ORR) in fuel cells. However, the intrinsically infirm nanoframes could be severely d... -
Collision Cross Sections and Ion Structures: Development of a General Calculation Method via High-quality Ion Mobility Measurements and Theoretical Modeling
Ion mobility mass spectrometry (IM-MS) has become an important tool for the structural investigation of ions in the gas phase. Accurate theoretical evaluation of ion collision cross sections (CCSs) is essential for the effective application... -
Total Syntheses of Arcyriaflavin A and Calothrixin B Using 2,2′-Bisindole-3-acetic Acid Derivative as a Common Intermediate
Sungjong Lee(석사과정) / Kyung-Hee Kim(박사과정) A new protocol for the synthesis of 2,2′-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyani... -
Synthesis, Characterization, and Efficient Catalytic Activities of a Nickel(II) Porphyrin: Remarkable Solvent and Substrate Effects on Participation of Multiple Active Oxidants
A new nickel(II) porphyrin complex, [NiII(porp)] (1), has been synthesized and characterized by 1H NMR, 13C NMR and mass spectrometry analysis. This NiII porphyrin complex 1 quantitatively catalyzed the epoxidation reaction of a wide range o...