| 첨부 '1' |
|---|
| author | Jong Seung Kim |
|---|---|
| journal | Angew. Chem. Int. Ed. 2013, 52, 6206-6209 |
| Homepage | http://orgchem.korea.ac.kr/index2.asp |
Abstract
High-tech pH paper : A “chameleon” pH probe composed of rhodamine (red, see scheme) and fluorescein (green) units emits at wavelengths of 580 nm and 512 nm, where the intensities show a contrary response to pH changes. Confocal microscopy of HeLa cells with this probe reveals red and green spots; the ratio of these signals can be calibrated to give the pH value of the respective organelle.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201301894/abstract
Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis ...
A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria
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Template-Guided Solution-Shearing Method for Enhanced Charge Carrier Mobility in Diketopyrrolopyrrole-Based Polymer Field-Effect Transistors
Template-guided solution-shearing (TGSS) is used to fabricate field-effect transistors (FETs) composed of micropatterned prisms as active channels. The prisms comprise highly crystalline PTDPP-DTTE, in which diketopyrrolopyrrole (DPP) is fla... -
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Mitochondrial Induced and Self-Monitored Intrinsic Apoptosis by Antitumor Theranostic Prodrug: In Vivo Imaging and Precise Cancer Treatment
Activation of apoptosis, the cell death machinery, in tumor cells by organelle-specific delivery of antitumor theranostic agent is the utmost challenge in cancer therapy. Herein, we developed a highly efficient mitochondria-targeting antitum... -
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Two-Color Probe to Monitor a Wide Range of pH Values in Cells
Abstract High-tech pH paper : A “chameleon” pH probe composed of rhodamine (red, see scheme) and fluorescein (green) units emits at wavelengths of 580 nm and 512 nm, where the intensities show a contrary response to pH changes. Confocal micr... -
Read More
A Self-Calibrating Bipartite Viscosity Sensor for Mitochondria
Abstract High-tech pH paper : A self-calibrating bipartite viscosity sensor 1 for cellular mitochondria, composed of coumarin and boron-dipyrromethene (BODIPY) with a rigid phenyl spacer and a mitochondria-targeting unit, was synthesized. Th... -
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Folate-Based Near-Infrared Fluorescent Theranostic Gemcitabine Delivery
Abstract A series of heptamethine cyanine (1−3) derivatives bearing a carbamate ethyl disulfide group and gemcitabine, an anticancer drug, have been newly synthesized. Their disulfide bonds are readily cleaved by various thiols including glu... -
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An Activatable Theranostic for Targeted Cancer Therapy and Imaging
Abstract A new theranostic strategy is described. It is based on the use of an “all in one” prodrug, namely the biotinylated piperazine-rhodol conjugate 4 a. This conjugate, which incorporates the anticancer drug SN-38, undergoes self-immola... -
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Toward a Chemical Marker for Inflammatory Disease: A Fluorescent Probe for Membrane-Localized
Abstract Thioredoxin (Trx) is a redox-active protein that plays a key role in mitigating the effects of oxidative stress. The secretion of Trx on the plasma membrane has been suggested as a distinctive feature of inflammation. However, selec...