| 첨부 '1' |
|---|
| author | Jong Seung Kim |
|---|---|
| journal | Chem (Cell press) DOI:https://doi.org/10.1016/j.chempr.2018.08.002 |
| Homepage | http://orgchem.korea.ac.kr/ |
Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here we report a new approach to overcoming resistance that involves reprogramming oncogene-directed alterations in mitochondrial metabolism prior to drug activation while simultaneously circumventing drug efflux pumps. Conjugate C1 increases cancer cell apoptosis and inhibits regrowth of drug-resistant tumors as inferred from efficacy studies carried out in human cancer cells and in Dox-resistant xenograft tumor models. It also displays minimal whole animal toxicity. These benefits are ascribed to an ability to evade chemoresistance by switching cancer cell metabolism back to normal mitochondrial oxidative phosphorylation while helping target the active Dox to first the mitochondrion and then the nucleus.
https://www.cell.com/chem/
Accurate Quantification of N-glycolylneuraminic Acid in Thera...
Janus Nanoparticle Structural Motif Control via Asymmetric Ca...
-
Read More
Accurate Quantification of N-glycolylneuraminic Acid in Therapeutic Proteins Using Supramolecular Mass Spectrometry
Hyun Hee L. Lee (이현희, 박사과정, 제1저자) / Chae Eun Heo (허채은, 박사과정, 제 2저자) Practical applications of innovative host-guest systems are challenging because of unexpected guest competitors and/or subtle environmental differences.... -
Read More
Overcoming Drug Resistance by Targeting Cancer Bioenergetics with an Activatable Prodrug
Nearly without exception, all known cancer chemotherapeutics elicit a resistance response over time. The resulting resistance is correlated with poor clinical outcomes. Here we report a new approach to overcoming resistance that involves rep... -
Read More
Janus Nanoparticle Structural Motif Control via Asymmetric Cation Exchange in Edge-Protected Cu1.81S@IrxSy Hexagonal Nanoplates
Post-synthetic transformation of nanoparticles has received great attention, because this approach can provide an unusual route to elaborately composition-controlled nanostructures while maintaining the overall structure of the template. In... -
Read More
Deconvolution of Tunneling Current in Large-area Junctions Formed with Mixed Self-Assembled Monolayers
Junji Jin(석사과정) Gyu Don Kong(박사과정) Whereas single-component self-assembled monolayers (SAMs) have served widely as organic components in molecular and organic electronics, how the performance of the device is influenced by the hetero... -
Read More
Electron heating and thermal relaxation of gold nanorods revealed by two-dimensional electronic spectroscopy
To elucidate the complex interplay between the size and shape of gold nanorods and their electronic, photothermal, and optical properties for molecular imaging, photothermal therapy, and optoelectronic devices, it is a prerequisite to charac... -
Read More
(Semi)ladder-Type Bithiophene Imide-Based All-Acceptor Semiconductors: Synthesis, Structure–Property Correlations, and Unipolar n-Type Transistor Performance
Development of high-performance unipolar n-type organic semiconductors still remains as a great challenge. In this work, all-acceptor bithiophene imide-based ladder-type small molecules BTIn and semiladder-type homopolymers PBTIn (n = 1–5) w... -
Read More
Dendrite-Embedded Platinum–Nickel Multiframes as Highly Active and Durable Electrocatalyst toward the Oxygen Reduction Reaction
Hyukbu Kwon(석사과정) Jongsik Park(박사과정) Pt-based nanoframe catalysts have been explored extensively due to their superior activity toward the oxygen reduction reaction (ORR). Herein, we report the synthesis of Pt–Ni multiframes, which ... -
Read More
Mid-Infrared Intraband Transition of Metal Excess Colloidal Ag2Se Nanocrystals
Mihyeon Park(석사과정) Dongsun Choi(박사과정) Steady-state intraband transition, which is a promising electronic transition of a colloidal quantum dot along with the band-gap transition, had been a long-standing challenge. The steady-state ... -
Read More
Enhanced Electron Transfer Mediated by Conjugated Polyelectrolyte and Its Application to Washing-Free DNA Detection
Ji-Eun Jeong (박사과정) Direct electron transfer between a redox label and an electrode requires a very short working distance (<1-2 nm), and in general an affinity biosensor based on the direct electron transfer requires a finely smoothed ... -
Read More
Vertex-reinforced PtCuCo ternary nanoframes as efficient and stable electrocatalysts for the oxygen reduction reaction and the methanol oxidation reaction
Taehyun Kwon(박사과정) / Minki Jun (박사과정) Noble metal binary alloy nanoframes have emerged as a new class of fuel cell electrocatalysts because of their intrinsic high catalytic surface area and accompanied high catalytic activity. Howe... -
Read More
Molecular Role of Ca2+ and Hard Divalent Metal Cations on Accelerated Fibrillation and Interfibrillar Aggregation of α-Synuclein
Jong Yoon Han(박사과정) / Tae Su Choi(Post doc.) α-Synuclein (αSyn) is an intrinsically disordered protein, the aggregation of which is highly related to the pathology of diverse α-synucleinopathies. Various hard divalent metal cations have... -
Read More
Supramolecular Modulation of Structural Polymorphism in Pathogenic α-Synuclein Fibrils Using Cu(II) Coordination
Tae Su Choi(Post doc.) / Jong Yoon Han(박사과정) Structural variation of α-synuclein (αSyn) fibrils has been linked to the diverse etiologies of synucleinopathies. However, little is known about what specific mechanism provides αSyn fibrils... -
Read More
Recent Progress in the Chemistry of Pyridazinones for Functional Group Transformations
Seohyun Kang(석사과정) While N-hetereocycles have received significant attention in organic synthesis and other research fields, the chemistry of pyridazine, six-membered aromatic ring with adjacent two nitrogen atoms, and its derivatives ... -
Read More
Maskless Arbitrary Writing of Molecular Tunnel Junctions
Seo Eun Byeon(석사과정) / Miso Kim(석사과정) Since fabricating geometrically well-defined, noninvasive, and compliant electrical contacts over molecular monolayers is difficult, creating molecular-scale electronic devices that function in h... -
Read More
Single Component Organic Solar Cells Based on Oligothiophene-Fullerene Conjugate
Thanh Luan Nguyen(Post doc.) A new donor (D)–acceptor (A) conjugate, benzodithiophene-rhodanine–[6,6]-phenyl-C61 butyric acid methyl ester (BDTRh–PCBM) comprising three covalently linked blocks, one of p-type oligothiophene containing BDTRh... -
Read More
Lanthanide metal-assisted synthesis of rhombic dodecahedral MNi (M=Ir and Pt) nanoframes toward efficient oxygen evolution catalysis
Haneul Jin(박사과정) / Yongju Hong(박사과정) Mixed metal alloy nanoframeworks have shown a great promise as electrocatalysts in water electrolyzers and fuel cells. Although a limited number of mixed metal alloy nanoframeworks have been synt... -
Read More
Radially Phase Segregated PtCu@PtCuNi Dendrite@Frame Nanocatalyst for the Oxygen Reduction Reaction
Hyukbu Kwon(석사과정) / Jongsik Park(박사과정) Pt-based alloy nanoframes have shown a great potential as electrocatalysts toward oxygen reduction reaction (ORR) in fuel cells. However, the intrinsically infirm nanoframes could be severely d... -
Read More
Collision Cross Sections and Ion Structures: Development of a General Calculation Method via High-quality Ion Mobility Measurements and Theoretical Modeling
Ion mobility mass spectrometry (IM-MS) has become an important tool for the structural investigation of ions in the gas phase. Accurate theoretical evaluation of ion collision cross sections (CCSs) is essential for the effective application... -
Read More
Total Syntheses of Arcyriaflavin A and Calothrixin B Using 2,2′-Bisindole-3-acetic Acid Derivative as a Common Intermediate
Sungjong Lee(석사과정) / Kyung-Hee Kim(박사과정) A new protocol for the synthesis of 2,2′-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyani... -
Read More
Synthesis, Characterization, and Efficient Catalytic Activities of a Nickel(II) Porphyrin: Remarkable Solvent and Substrate Effects on Participation of Multiple Active Oxidants
A new nickel(II) porphyrin complex, [NiII(porp)] (1), has been synthesized and characterized by 1H NMR, 13C NMR and mass spectrometry analysis. This NiII porphyrin complex 1 quantitatively catalyzed the epoxidation reaction of a wide range o...